Regional anesthesia and pain medicine
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Reg Anesth Pain Med · Mar 2012
Electron-microscopic imaging of endothoracic fascia in the thoracic paravertebral space in rats.
Anesthesia and analgesia with paravertebral block are reportedly variable. Existence of an endothoracic fascia has been proposed as one of the possible mechanisms leading to variability. We undertook an electron-microscopy imaging study to investigate the endothoracic fascia in the thoracic paravertebral space (TPS) in rats. ⋯ The endothoracic fascia in rats appears to divide the TPS into EPC and SETC. These anatomic characteristics may have implications in thoracic paravertebral blockade.
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Reg Anesth Pain Med · Mar 2012
Prolongation of epidural analgesia using solid lipid nanoparticles as drug carrier for lidocaine.
Solid lipid nanoparticles (SLNs), as a drug carrier, are a very attractive strategy for sustained and controlled drug release. In this study, we investigated the feasibility of SLNs to prolong the action of lidocaine for potential application in epidural anesthesia and analgesia. ⋯ Solid lipid nanoparticles can be exploited as a promising drug carrier for extending the action of lidocaine.