Regional anesthesia and pain medicine
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Reg Anesth Pain Med · Mar 2012
Prolongation of epidural analgesia using solid lipid nanoparticles as drug carrier for lidocaine.
Solid lipid nanoparticles (SLNs), as a drug carrier, are a very attractive strategy for sustained and controlled drug release. In this study, we investigated the feasibility of SLNs to prolong the action of lidocaine for potential application in epidural anesthesia and analgesia. ⋯ Solid lipid nanoparticles can be exploited as a promising drug carrier for extending the action of lidocaine.