Regional anesthesia and pain medicine
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Reg Anesth Pain Med · Mar 2013
Letter Randomized Controlled TrialContinuous interscalene nerve block following adhesive capsulitis manipulation.
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Reg Anesth Pain Med · Mar 2013
Thermal hyperalgesia after sciatic nerve block in rat is transient and clinically insignificant.
Ropivacaine has been associated with transient heat hyperalgesia in sciatic nerve blocks in rat. The goal of the present study was to evaluate the hypothesized presence of transient heat hyperalgesia after perineural injection of ropivacaine with a secondary subanalysis of 2 published studies. ⋯ Although statistically significant, the single time point measurement represented only an 11% change from baseline and was no longer present 30 minutes later. These data support the need for a reevaluation of the interpretation that pain can be worsened by perineural ropivacaine injection.
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Reg Anesth Pain Med · Mar 2013
Epinephrine administered with lidocaine solution does not worsen intrathecal lidocaine neurotoxicity in rats.
Epinephrine can potentially worsen the neurotoxic effects of local anesthetics when used for spinal or epidural anesthesia. The vasoconstrictive property of epinephrine reduces dural blood flow, which in turn reduces the clearance of local anesthetics from the subarachnoid space. This study examined the histological and neurofunctional effects of intrathecally administered lidocaine combined with epinephrine in rats. ⋯ Intrathecal epinephrine prolonged the action of intrathecal lidocaine but did not worsen lidocaine-induced histological damage and functional impairment.
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Reg Anesth Pain Med · Mar 2013
Resveratrol facilitates pain attenuation in a rat model of neuropathic pain through the activation of spinal Sirt1.
Little research has been conducted regarding the implications of Sirt1 (a classic III HDAC) in neuropathic pain. The aim of this study was to investigate the variation in the expressions of spinal Sirt1 and acetyl-histone H3 in a rat model of chronic constriction injury. ⋯ Our data provide new evidence for the contribution of spinal Sirt1 to the initiation and maintenance of neuropathic pain. The antinociceptive effects of resveratrol may be mediated through the activation of spinal Sirt1 in CCI rats.