Regional anesthesia and pain medicine
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Reg Anesth Pain Med · Jan 2015
Comparative StudyEffects of Sodium Bisulfite With or Without Procaine Derivatives on Axons of Cultured Mouse Dorsal Root Ganglion Neurons.
Sodium bisulfite (NaHSO3) was clinically used as a preservative agent for local anesthetics but was later suspected to be neurotoxic. However, recent studies reported that NaHSO3 reduces the neurotoxicity of local anesthetics. The purpose of this study was to examine the effects of NaHSO3 with and without procaine on axonal transport in cultured mouse dorsal root ganglion (DRG) neurons. ⋯ NaHSO3 resulted in a dose-dependent damage to the cell membrane and axonal transport, especially when used in combination with procaine or chloroprocaine.
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Reg Anesth Pain Med · Jan 2015
Randomized Controlled Trial Comparative StudyA Randomized Comparison Between Ultrasound- and Fluoroscopy-Guided C7 Medial Branch Block.
Because of its location in the lower neck and anatomical variability, the C7 medial branch represents a challenging target for local anesthetic blocks. Although ultrasound (US) guidance offers an alternative to fluoroscopy for C3 to C6 cervical medial branch blocks (CMBBs), its use at the C7 level has not been examined. We hypothesized that US, using a biplanar imaging technique, could provide a shorter performance time than conventional fluoroscopy for C7 CMBB. ⋯ Ultrasound guidance using a biplanar approach provides a similar success rate to fluoroscopy for C7 CMBB. However, US is associated with improved efficiency (decreased performance time and fewer needle passes).