Regional anesthesia and pain medicine
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Reg Anesth Pain Med · Jan 1998
Case ReportsThe use of 5% lidocaine for prolonged analgesia in chronic pain patients: a new technique.
It has been found that 5% lidocaine with 7.5% dextrose causes irreversible conduction block in animal studies. Our case report subjects allowed us to observe the efficacy of 5% lidocaine for a prolonged analgesia in vivo. ⋯ Our observations suggest that 5% lidocaine may be used safely and effectively for the purpose of prolonged analgesia in selected patients with intractable chronic pain syndromes.
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Reg Anesth Pain Med · Jan 1998
Randomized Controlled Trial Clinical TrialIncisional morphine has no analgesic effect on postoperative pain following inguinal herniotomy.
Opioids induce antinociceptive effects after peripheral administration in experimental and clinical studies. The results of the clinical studies are conflicting. The objective of this study was to examine a possible analgesic effect of incisionally administered morphine on postoperative pain in patients undergoing inguinal herniotomy during general anesthesia. ⋯ The analgesic effect of a single 5 mg dose of morphine injected in a herniotomy wound is not superior to saline or to morphine given subcutaneously or intravenously.
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Reg Anesth Pain Med · Jan 1998
Randomized Controlled Trial Clinical TrialEnhancement of analgesic effect of intrathecal neostigmine and clonidine on bupivacaine spinal anesthesia.
Intrathecal administration of neostigmine has been shown to produce analgesia in both animals and humans. The concurrent administration of intrathecal neostigmine and clonidine has been reported to produce no neurotoxicity in sheep. The purpose of the present study was to evaluate the efficacy and safety of the combining intrathecal neostigmine and clonidine for the relief of pain in patients after cesarean delivery. ⋯ Our study showed that the combination of 150 microg i.t. clonidine and 50 microg neostigmine provided longer postsurgical analgesia than with either drug used alone. However, this combination also produced significantly more adverse effects of prolonged motor block and nausea and vomiting. A further study combining the two study drugs but using a lower dose of i.t. neostigmine (e.g., 25 microg) is recommended.
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Reg Anesth Pain Med · Jan 1998
Case ReportsParaplegia following intracord injection during attempted epidural anesthesia under general anesthesia.
A case of permanent paraplegia is reported following attempted epidural anesthesia for a total knee replacement in a 62-year-old woman with a history of lumbar laminectomy for a prolapsed intervertebral disc. ⋯ Standards of management are discussed in relation to this case.