La Clinica terapeutica
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La Clinica terapeutica · Jul 2008
Review[Scoring of disseminated intravascular coagulation (DIC) in intensive care medicine].
A close association between disseminated intravascular coagulation (DIC) and increased morbidity and mortality of the critically ill has been uncovered in the ongoing validation of newly developed scoring systems of DIC. DIC scoring aims at quantifying and standardizing pathological activation of coagulation in these patients. ⋯ Promising data on targeted modification of DIC by administration of antithrombin has been reported in the past, however, randomized controlled trials on the use of antithrombin for the treatment of DIC are still few. Early detection of DIC by application of novel scores could play a particular role in future DIC trials by defining patient populations most likely to benefit from targeted intervention in their clotting disturbance of critical illness.