Langenbeck's archives of surgery
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Langenbecks Arch Surg · Oct 2014
Randomized Controlled Trial Multicenter StudyHemostatic efficacy of latest-generation fibrin sealant after hepatic resection: a randomized controlled clinical study.
This randomized, controlled, single-blinded multicenter study evaluated the efficacy of latest-generation fibrin sealant containing synthetic aprotinin as fibrinolysis inhibitor as supportive treatment for hemostasis after elective partial hepatectomy. ⋯ Fibrin sealant was shown to be safe and superior to manual compression in the control of parenchymal bleeding after hepatic resection. The use of synthetic aprotinin as fibrinolysis inhibitor further improves the safety margin of fibrin sealant by eliminating the risk of transmission of bovine spongiform encephalopathy and other bovine pathogens.