Pharmaceutical biology
-
Pharmaceutical biology · Nov 2013
Magnesium lithospermate B reduces myocardial ischemia/reperfusion injury in rats via regulating the inflammation response.
Magnesium lithospermate B (MLB), an active polyphenol acid of Danshen [Radix Salviae miltiorrhizae (Labiatae)], showed renoprotective, neuroprotective and myocardial salvage effects. Previous studies demonstrated that MLB could effectively suppress the production of cytokines and their associated signaling pathways in activated human T cells. ⋯ Our study provided evidence that MLB ameliorated the inflammatory process associated with MI/R injury via NF-κB inactivation.