Pharmaceutical biology
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Pharmaceutical biology · Nov 2016
Meta AnalysisReduced colorectal cancer incidence in type 2 diabetic patients treated with metformin: a meta-analysis.
Diabetic patients have a higher risk of colorectal cancer (CRC). The role of metformin in CRC incidence among type 2 diabetes mellitus (T2DM) remains controversial. ⋯ In conclusion, the meta-analysis suggests metformin may reduce CRC incidence among diabetics, which is useful medical information for clinicians.
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Pharmaceutical biology · Nov 2016
Protective effect of Pycnogenol on cisplatin-induced ototoxicity in rats.
Pycnogenol®, which is French maritime pine bark extract, is a potent antioxidant. It is used in medical conditions caused by oxidative stress. Cisplatin (cis-diamminedichloroplatinum II) is an antineoplastic agent. However, its serious side effects such as ototoxicity limit its usage. ⋯ Pycnogenol protected against cisplatin ototoxicity. Also, pycnogenol is not ototoxic.