The international journal of neuropsychopharmacology

The most recent articles from: Int. J. Neuropsychopharmacol. August 2016

Int. J. Neuropsychopharmacol. · Aug 2016

Randomized Controlled Trial Multicenter Study

A Phase II Dose-Ranging Study Evaluating the Efficacy and Safety of the Orexin Receptor Antagonist Filorexant (MK-6096) in Patients with Primary Insomnia.

Filorexant (MK-6096) is an orexin receptor antagonist; here, we evaluate the efficacy of filorexant in the treatment of insomnia in adults. ⋯ Orexin receptor antagonism by filorexant significantly improved sleep efficiency in nonelderly patients with insomnia. Dose-related improvements in sleep onset and maintenance outcomes were also observed with filorexant.

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