The international journal of neuropsychopharmacology
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Int. J. Neuropsychopharmacol. · Aug 2017
Randomized Controlled TrialAcute and Chronic Noradrenergic Effects on Cortical Excitability in Healthy Humans.
Noradrenaline is a major neuromodulator in the central nervous system, and it is involved in the pathophysiology of diverse neuropsychiatric diseases. Previous transcranial magnetic stimulation studies suggested that acute application of selective noradrenaline reuptake inhibitors enhances cortical excitability in the human brain. However, other, such like clinical effects, usually require prolonged noradrenaline reuptake inhibitor treatment, which might go along with different physiological effects. ⋯ The results show physiological mechanisms of noradrenergic enhancement possibly underlying the functional effects of reboxetine regarding acute and chronic application.