Circulation research
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Circulation research · Oct 2012
Induction of cardiomyocyte-like cells in infarct hearts by gene transfer of Gata4, Mef2c, and Tbx5.
After myocardial infarction (MI), massive cell death in the myocardium initiates fibrosis and scar formation, leading to heart failure. We recently found that a combination of 3 cardiac transcription factors, Gata4, Mef2c, and Tbx5 (GMT), reprograms fibroblasts directly into functional cardiomyocytes in vitro. ⋯ GMT gene transfer induced cardiomyocyte-like cells in infarcted hearts.
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Circulation research · Oct 2012
Editorial CommentAn emerging strategy of gene therapy for cardiac disease.