J Emerg Med
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Review Case Reports
Acquired hemophilia presenting as profound hematuria: evaluation, diagnosis, and management of elusive cause of bleeding in the emergency department setting.
There are numerous causes of bleeding that may present to the Emergency Department (ED). Although rare, acquired hemophilia is a potentially life-threatening bleeding disorder, with reported mortality rates ranging from 6% to 8% among patients who received proper diagnosis and treatment. Approximately two thirds of patients with this condition will present with major bleeding, the magnitude of which may necessitate urgent evaluation and care. ⋯ Patients with acquired hemophilia-related bleeding may present to the ED for care, given the often serious nature of their bleeding. Delayed diagnosis may postpone the initiation of targeted, effective treatments for achieving hemostasis, with potentially catastrophic consequences, particularly in patients who require emergent invasive procedures. Recognition of the potential for an underlying bleeding disorder and subsequent consultation with a hematologist are critical first steps in effectively identifying and managing a patient with acquired hemophilia who presents with bleeding.
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Hypothenar hammer syndrome is a rare vascular overuse syndrome characterized by post-traumatic vascular insufficiency of the hand from repetitive compression over the hypothenar eminence. Patients with occupations predisposing to repetitive use of the hypothenar eminence as a tool are at high risk. Repetitive trauma compresses a superficial segment of the ulnar artery against the hook of hamate as it exits Guyon's canal, damaging the intimal layer of the artery and causing vasospasm, platelet aggregation, and thrombus formation, leading to pain and paresthesias that eventually progress to claudication and ischemia. ⋯ This case report illustrates a rare clinical condition that with prompt and early identification by Emergency Physicians can prevent significant morbidity and progression of disease. The epidemiology, clinical features, and diagnosis are discussed along with a review of the relevant literature regarding available treatment options.
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Review
Review of recently approved alternatives to anticoagulation with warfarin for emergency clinicians.
Dabigatran and rivaroxaban are novel anticoagulants that have been approved for the prevention of thromboembolic events in atrial fibrillation. These medications are attractive to both patients and clinicians, as, unlike warfarin, they do not require laboratory monitoring or dietary restrictions. However, they carry bleeding risks similar to that of warfarin and are without a reliable reversal agent. ⋯ There is a need for assays for the degree of anticoagulation produced by drugs such as dabigatran and rivaroxaban. Additionally, studies are needed to evaluate reversal agents that could be effective in the setting of acute bleeding.
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Review
Is emergency department cardioversion of recent-onset atrial fibrillation safe and effective?
Atrial fibrillation (AF) is a very common dysrhythmia presenting to Emergency Departments (EDs). Controversy exists regarding the optimal clinical therapy for these patients, which typically focuses on rhythm rate-control and admission or cardioversion and discharge home. ⋯ ED cardioversion for recent-onset AF seems safe and effective.