J Emerg Med
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Randomized Controlled Trial Comparative Study
GlideScope vs. C-MAC for Awake Upright Laryngoscopy.
Combining video laryngoscopy with awake upright intubation may provide an alternative modality of endotracheal intubation (ETI) that avoids pitfalls associated with traditional ETI. ⋯ GlideScope provides superior views to C-MAC in awake upright laryngoscopy in healthy volunteers.
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Porphyrias are a group of eight metabolic disorders characterized by defects in heme biosynthesis. Porphyrias are classified into two major categories: 1) the acute or inducible porphyrias and 2) the chronic cutaneous porphyrias. The acute hepatic porphyrias are further classified into acute intermittent porphyria (AIP), hereditary coproporphyria, variegate porphyria, and porphyria due to severe deficiency of delta-aminolevulinic acid (ALA) dehydratase (ALADP). ⋯ Once suspected, the diagnosis of porphyria can be rapidly established by checking random urinary porphobilinogen. Initial management of acute porphyria includes discontinuation of all potentially harmful drugs and management of symptoms. Acute attacks should be treated emergently with intravenous heme and glucose to avoid considerable morbidity and mortality. Acute attacks last a few days, and the majority of patients are asymptomatic between attacks. Prognosis is good if the condition is recognized early and treated aggressively.
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The predictive role of lactate in critically ill patients with acute upper gastrointestinal bleeding (UGIB) remains to be elucidated. ⋯ In patients admitted to the ICU with acute UGIB, lactate level on admission has a high sensitivity but low specificity for predicting in-hospital death. Lactate level adds to the predictive value of the clinical Rockall score. Given its high sensitivity, lactate level can be used in addition to other prediction tools to predict outcomes in patients with UGIB.
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Case Reports
Cervical Spine Fracture Presenting as an Orthostatic Headache Secondary to Cerebral Spinal Fluid Leak.
Head injuries are a common chief complaint encountered in the emergency department (ED). A cerebrospinal fluid (CSF) leak resulting from such injuries is uncommon, but has potentially debilitating consequences if undiagnosed. ⋯ A 34-year-old male patient presented to the ED with complaints of an orthostatic headache after a bicycle accident that occurred 5 days prior to presentation. He presented with a nonfocal neurologic examination. Computed tomography (CT) of the head was without significant pathology. CT angiography of the neck, performed due to a concern about traumatic arterial dissection, revealed C7 spinal fractures, but no evidence of dissection or occlusion of the arteries in the neck. Lying flat, he appeared comfortable but became quite symptomatic upon sitting upright or standing. Based on this finding, a CSF leak was suspected and he was admitted for symptom control and more detailed imaging to rule out such a leak. He was found, on magnetic resonance imaging, to have epidural CSF collections consistent with the suspected leak. In addition to immobilization for the cervical spine fracture, he was treated for orthostatic headaches conservatively with good outcomes. WHY SHOULD AN EMERGENCY PHYSICIAN BE AWARE OF THIS?: Although this syndrome is still considered rare compared to other posttraumatic injuries, there is a growing body of evidence suggesting it may be underdiagnosed. Additionally, the signs and symptoms of this syndrome are nonspecific, with the exclusion of the orthostatic headache, and may be readily attributed to other diagnoses.