J Trauma
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Comparative Study
Diagnostic utility of sublingual PCO2 for detecting hemorrhage in penetrating trauma patients.
Hemorrhage results in early compromise of splanchnic circulation. Studies have shown that sublingual Pco2 (SLCO2) correlates with gut perfusion. We tested SLCO2's ability to detect hemorrhage. We compared SLCO2 with arterial base deficit (BD) and lactate (LAC). ⋯ SLCO2 differentiated blood loss groups. SLCO2 may be useful in triage of penetrating trauma patients.
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Randomized Controlled Trial Clinical Trial
Evaluation of poly-N-acetyl glucosamine as a hemostatic agent in patients undergoing cardiac catheterization: a double-blind, randomized study.
This is the first blinded, randomized, placebo-controlled clinical trial to evaluate the efficacy of poly-N-acetyl glucosamine (p-GLcNAc) in improving hemostasis in patients undergoing cardiac catheterization. ⋯ The application of p-GlcNAc patches improved hemostasis at the arterial puncture site in patients undergoing cardiac catheterization.
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Clinical Trial Controlled Clinical Trial
The impact of hypoxia and hyperventilation on outcome after paramedic rapid sequence intubation of severely head-injured patients.
An increase in mortality has been documented in association with paramedic rapid sequence intubation (RSI) of severely head-injured patients. This analysis explores the impact of hypoxia and hyperventilation on outcome. ⋯ Hyperventilation and severe hypoxia during paramedic RSI are associated with an increase in mortality.
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Little is known about the influence of regionalization of trauma care on pediatric trauma care delivery. The purpose of this study was to estimate whether formal adoption of a statewide trauma system was associated with hospital admission patterns of injured children. ⋯ Trauma designation in Washington was associated with a shift in admissions from nondesignated hospitals to pediatric trauma hospitals.
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The safety and efficacy of poly-N-acetyl glucosamine (p-GlcNAc) gels were compared with standard agents in three different dog studies to assess abdominal venous collaterals, bleeding esophageal varices, and bleeding gastric varices. ⋯ F2 and F4 poly-N-acetyl glucosamine gels are promising therapeutic agents for venous and variceal hemostasis.