Cancer
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Randomized Controlled Trial Multicenter Study Clinical Trial
Intravenous pamidronate disodium treatment of bone metastases in patients with breast cancer. A dose-seeking study.
Treatment of the symptoms of bone metastases currently involves the use of narcotic medication, radiation therapy, or hormonal therapy. Pamidronate disodium, a bisphosphonate, may prove helpful in the palliative treatment of bone metastases in patients with breast cancer as demonstrated in this multicenter, dose-ranging trial. ⋯ Intravenous pamidronate is a well tolerated treatment that produced significant relief of bone pain in the majority of patients with metastatic breast cancer at the three highest doses tested.