Arch Surg Chicago
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Randomized Controlled Trial Comparative Study Clinical Trial
Lipolysis in burned patients is stimulated by the beta 2-receptor for catecholamines.
To determine if the cardiovascular effects of excessive catecholamines could be selectively blocked in severely burned patients without adversely affecting protein or fat kinetics. ⋯ Selective beta 1-adrenergic blockade did not reduce lipolysis; however, a beta 1- and beta 2-adrenergic blockade significantly reduced lipolysis. Thus, the increased lipolysis, characteristic of severely burned patients, is caused by stimulation of the beta 2-adrenergic receptors for catecholamines.