Arch Surg Chicago
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Randomized Controlled Trial Clinical Trial
Effect of pentoxifylline in severe sepsis: results of a randomized, double-blind, placebo-controlled study.
To evaluate the effect of pentoxifylline on organ dysfunction, survival, and mediator response in patients with severe sepsis. ⋯ Continuous intravenous administration of pentoxifylline beneficially influenced cardiopulmonary dysfunction in patients with sepsis without adverse effects. Larger trials are needed to evaluate the efficacy in improving organ function in relation to the outcome for patients with severe sepsis.