Cent Eur Neurosurg
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Melatonin is an important antioxidant agent with a protective role in the prevention of oxidative stress. We designed an experimental study which focused on the potential neuroprotective effect of melatonin on peripheral nerve injury. ⋯ With its neuroprotective effect, as demonstrated in this experimental peripheral nerve injury, melatonin might be used successfully in clinical practice. Further studies on the correct dosage and possible side effects are necessary.
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The study aimed to evaluate the anatomical relations of sellar and perisellar structures with T2-weighted MRI and to apply criteria for cavernous sinus (CS) invasion by pituitary adenomas to normal sellar anatomy. ⋯ Inter- and intra-individual variations of the perisellar anatomy and its relation to the pituitary gland exist, which are partly related to age and AH. This must be remembered when the invasiveness of pituitary adenomas is assessed in MRI.
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Lumbar disc surgery is one of the procedures performed early in neurosurgical training. Agreement exists concerning the use of microsurgical techniques. With increasing surgical experience the clinical outcome should improve, partly because of a reduction in the complication rate. The aim of this study was to evaluate the correlation between patients' immediate clinical outcome, the perioperative complication rate and the surgeons' level of experience. ⋯ The clinical outcome after surgery for lumbar disc herniation does not improve linearly with the surgeon's experience. The intraoperative complication rate is highest between the 3rd and the 6th year of training.