Minerva anestesiologica
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Minerva anestesiologica · Apr 2010
Randomized Controlled Trial Comparative StudyComparison of two ketamine-propofol dosing regimens for sedation during interventional radiology procedures.
Invasive diagnostic and therapeutic interventional radiological procedures can be painful and anxiety provoking. The combination of propofol and ketamine may minimize the need for supplemental opioid analgesics and has the potential to provide better sedation with less toxicity than either drug alone. ⋯ In conclusion, the two different dosages of ketamine coadministered with propofol for sedation during interventional radiological procedures showed no clinically significant hemodynamic changes or side effects, and both appeared to prompt early recovery time. We recommend propofol 0.5 mg.kg-1 + ketamine 0.5 mg.kg-1 for sedation and analgesia during interventional radiological procedures, rather than propofol 0.5 mg.kg-1 + ketamine 0.25 mg.kg-1 because the former combination is associated with reduced rescue propofol requirements and therefore less oversedation.
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Minerva anestesiologica · Apr 2010
Randomized Controlled TrialEffects of fenoldopam infusion in complex cardiac surgical operations: a prospective, randomized, double-blind, placebo-controlled study.
Fenoldopam mesylate is a short-acting dopamine-1 agonist that has been suggested to be a possible reno-protective agent in patients undergoing cardiac surgery. The present study is a prospective, randomized, double-blind placebo controlled trial conducted to determine the effects of fenoldopam in a population of patients undergoing complex cardiac operations. ⋯ Fenoldopam improves the quality of perfusion during CPB. In patients receiving catecholamines to treat a postoperative low cardiac output state, fenoldopam significantly improves renal function and prevents AKI and major morbidity.