Minerva anestesiologica
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Minerva anestesiologica · Nov 2011
Review Comparative StudyCoxibs: is there a benefit when compared to traditional non-selective NSAIDs in postoperative pain management?
A multi-modal approach for the management of postoperative pain has become increasingly popular. Strategies to avoid the use of opioids and thus any opioid analgesic related side-effect is an important part of the expansion of ambulatory surgery. Combining long acting local anesthesia in the wound area and non-opioid analgesics are today a basic concept in management of day care, short stay patients. ⋯ The less pronounced effect on platelet function and subsequent lower risk for impaired hemeostasis makes them, in theory, a preferred option to the non-selective traditional NSAIDs. The benefit versus risk for a more generalized use of Coxibs must, however, be based on a thorough evaluation of the overall benefits and risks for the use of NSAIDs and a further evaluation on whether the specific therapeutic features of the Coxibs provide benefits outweighing their increased cost. This review aims at providing a background and an overview of the benefits versus risks for the use of Coxibs as part of a multimodal postoperative pain management.
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Enteral nutrition (EN) is a well established approach to nutritional support in the ICU. Parenteral nutrition (PN) represents an additional safe approach, substituting or complementing EN when its delivery fails completely or partially. This article attempts to summarize the ESPEN guidelines of PN in the ICU based on the available literature, which is often limited due to quality and methodology heterogeneity; the recommendations are therefore largely expressed as expert opinions.
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Minerva anestesiologica · Nov 2011
Review Meta AnalysisPediatric delirium in the pediatric intensive care unit: a systematic review and an update on key issues and research questions.
There was a dearth in awareness and knowledge regarding pediatric delirium (PD) at the pediatric intensive care unit (PICU). The aim of this study is to highlight the most recent and up-to-date findings of current literature -by means of a systematic review (SR) method-, and to present the key issues and research questions. ⋯ There still is a dearth of literature on PD, with also a variable level of evidence (1b - 5), especially in relation to critical illness. To be able to further clarify PD in the PICU, additional research questions are provided for future research.