Minerva anestesiologica
-
Minerva anestesiologica · Jan 2014
Multicenter Study Observational StudyAccuracy of leptin serum level in diagnosing ventilator-associated pneumonia: a case-control study.
Undernutrition causes a reduction of body-fat mass and a decrease in the circulating concentration of leptin which impairs the production of proinflammatory cytokines and increases the incidence of infectious diseases. The main objective of this study was to determine whether leptin deficiency is a risk factor for ventilator-associated pneumonia (VAP). ⋯ In our study, leptin level was not associated with VAP occurrence. Further studies are needed to confirm our results, and to define the exact inflammatory role of leptin, and its interest as a biomarker in ICU patients.