Minerva anestesiologica
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Minerva anestesiologica · Apr 2021
Randomized Controlled TrialEffect of dexmedetomidine on CD4+ T cells and programmed cell death protein-1 in postoperative analgesia: a prospective, randomized, controlled study.
Surgical trauma inhibits cellular immunity. Dexmedetomidine produces opioid-sparing effect and an impact on immune response. ⋯ Dexmedetomidine increases the differentiation of Th1 and Treg cells and reduces the expression of PD-1 on CD4+ T cells. Dexmedetomidine may assist to ameliorate postoperative pain and attenuate proinflammatory response. There might be a negative correlation between pain and Th1 cells.
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Minerva anestesiologica · Apr 2021
Randomized Controlled TrialComparison of the analgesic effect of quadratus lumborum block and epidural block in open uterine surgery: a randomized controlled trial.
Effective regional analgesia during open surgery could reduce opioid consumption and enhance early recovery. We compared the effects of the newly developed quadratus lumborum block (QLB) and the traditional epidural block (EB) in open uterine surgery. ⋯ QLB produces a less intense but longer block and fewer side effects in the first 24 h after open uterine surgery than those produced by EB.
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Minerva anestesiologica · Apr 2021
Randomized Controlled TrialThe Oxygen Reserve Index as a determinant of the necessary amount of postoperative supplemental oxygen.
Although blood gas analysis (BGA) is important for supplemental oxygen titration, it is invasive, intermittent, costly, and burdensome for staff. We assessed whether the Oxygen Reserve Index (ORi™), a novel pulse oximeter-based index that reflects the partial pressure of oxygen (PaO
2 ), could determine the amount of postoperative supplemental oxygen. We also evaluated the extent of hyperoxia and hypoxia. ⋯ Based on our results, ORi might be useful to titrate postoperative oxygen supplementation.