Surg Neurol
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Randomized Controlled Trial Clinical Trial
Study on therapeutic mechanism and clinical effect of mild hypothermia in patients with severe head injury.
The therapeutic mechanism and clinical effect of mild hypothermia in patients with severe head injury were studied. ⋯ Mild hypothermia is safe and effective for preventing brain damage on patients with severe head injury, as well as reducing mortality and improving the prognosis. It is important to monitor P(bt)O2, BT, CBF, and S(jv)O2 in hypothermic therapy.
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Randomized Controlled Trial Clinical Trial
Local wound infiltration with bupivacaine in lumbar laminectomy.
Parenteral administration of narcotics has been the mainstay for postoperative pain relief in patients undergoing lumbar laminectomy. However, this may lead to respiratory depression and nausea, which may be hazardous in these patients. ⋯ Local wound infiltration with bupivacaine is a safe and effective method for providing postoperative pain relief and reducing narcotic use in patients undergoing lumbar laminectomy.
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Randomized Controlled Trial Clinical Trial
Tranexamic acid in the preoperative management of ruptured intracranial aneurysms.
A randomized, controlled clinical trial was carried out to study the effect of tranexamic acid (AMCA, trans-AMCHA) in prevention of early rebleeding after proven rupture of an intracranial aneurysm. The series comprises 46 patients admitted to the hospital within three days after the first bleeding. ⋯ Nine patients in the control group and one in the group treated with tranexamic acid had confirmed rebleeding. The incidence of vasospasm, cerebral ischemia and hydrocephalus as well as mortality and morbidity is discussed.