World Neurosurg
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The α2 agonist dexmedetomidine (DEX) is an anesthetic agent that can provide sedation and analgesia without respiratory depression or changes in neuronal activity during microrecordings. The aim of our study was to confirm the efficacy and safety of anesthesia with DEX for unilateral deep brain stimulation of the subthalamic nucleus (STN) in patients with Parkinson disease. ⋯ The results of our study confirm that the use of DEX in managing patients with Parkinson disease during unilateral deep brain stimulation of the STN is safe and effective and can be considered a promising option for sedation during this type of procedure.
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Review Biography Historical Article
Ralph Bingham Cloward (1908-2000): Spine Polymath.
Dr. Ralph Bingham Cloward, an American neurosurgeon, revolutionized the field of modern spine surgery with his lifelong innovative and pioneering contribution. ⋯ He was also the first person to set up a bone bank in the United States. He rightfully deserves the title "Michelangelo of neurosurgery" for his exceptional work.
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Review Case Reports
Flow-related aneurysm within glioblastoma: A case report and review of literature.
Glioblastoma multiforme (GBM) is the most common primary brain tumor in adults, with a median survival of 13 months despite surgery and chemoradiation. GBMs are often hypervascular tumors caused by abnormal oversecretion of growth factors such as vascular endothelial growth factor. These angiogenic factors are hypothesized to promote increased blood flow and possibly secondary changes to arterial walls, thus facilitating the formation of flow-related aneurysms. ⋯ Hypervascular lesions, such as GBMs, may be associated with flow-related aneurysms on feeding arteries, but aneurysms within the gross tumor are unusual. Although rare, this finding needs to be recognized on preoperative imaging before tumor resection to prevent potentially catastrophic intraoperative complications.