World Neurosurg
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Review Meta Analysis
Surgical Outcomes of Laser Interstitial Thermal Therapy for Temporal Lobe Epilepsy: Systematic Review and Meta-analysis.
Laser interstitial thermal therapy (LITT) has emerged as a safe and effective approach to the treatment of temporal lobe epilepsy (TLE). The relationship of ablation volume with postoperative outcomes remains an area of contention. ⋯ The findings show a pooled seizure freedom rate of 58% for all patients with TLE and 66% for patients with MTS undergoing LITT. The evidence is insufficient to support a significant relationship of seizure freedom rate with total ablation volume as well as hippocampal or amygdala ablation.
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Review Case Reports
Genetically confirmed CARASIL: A case report with a novel HTRA1 mutation and literature review.
Cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL) is an extremely rare monogenic autosomal disease associated with the HtrA serine protease 1 (HTRA 1) gene mutation. Recently, a few genetically confirmed CARASIL cases with novel HTRA1 mutations have been reported in countries other than Japan. ⋯ CARASIL is a rare autosomal recessive disease with an HTRA1 mutation. Familiarity with the early clinical and imaging features of CARASIL combined with a genetic test is key for its early diagnosis.
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Meta Analysis
Optimizing Radiosurgery for Trigeminal Neuralgia: Impact of Radiation Dose and Anatomic Target on Patient Outcomes.
Radiosurgery is an increasingly popular treatment for trigeminal neuralgia (TN); however, several treatment variables require further study. This meta-analysis was conducted to clarify ambiguity in the literature and optimize treatment parameters. ⋯ Higher radiation dose was associated with superior pain control without increasing bothersome numbness. Independent of dose, the distal target was also associated with improved pain control. Bothersome numbness was not related to dose or target.