World Neurosurg
-
The neurofibromatosis type 2 (NF2) gene mutation is the leading genetic event in meningiomas, usually accompanied by malignant features. Dysfunction of the spindle assembly checkpoint (SAC) induces tumorigenesis. However, the crosstalk between NF2 and SAC in meningiomas remains unclear. ⋯ Our findings suggested that NF2 might restore SAC function by impairing the binding of APC/C and Cdc20, thereby limiting the mitotic rate and inhibiting proliferation of meningiomas.
-
Cerebral cavernous malformations are abnormal clusters of thin-walled sinusoidal vascular channels without intervening brain parenchyma. The most common presenting symptom is seizure, which results from hemosiderin deposition in surrounding tissues. Early surgical resection of these malformations confers the greatest likelihood of long-term seizure freedom. ⋯ The patient remained free of seizures through the 6-month follow-up. Video 1 demonstrates the cSCTT approach to lesions of the posterior mediobasal temporal lobe without the need for retraction or transcortical dissection. The cSCTT approach extends the reach of the ipsilateral, infratentorial approach laterally, which is nearly 2 cm off midline, more than is possible without cutting the tentorium.
-
Chondrosarcomas of the skull base are rare tumors most commonly treated surgically with or without adjuvant radiation therapy. Using the National Cancer Database (NCDB), we analyzed overall survival (OS), treatment modalities, and prognosticators. ⋯ The mainstay of treatment for skull base chondrosarcoma is surgery, with consideration of adjuvant radiation. This study demonstrated worse overall survival associated with more frail patients and aggressive histology types. It is important to consider these factors when planning the clinical management of these patients.