The Journal of clinical endocrinology and metabolism
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J. Clin. Endocrinol. Metab. · Jul 2007
Multicenter StudyAssociations of adiponectin with body fat distribution and insulin sensitivity in nondiabetic Hispanics and African-Americans.
Hypoadiponectinemia has emerged as an independent risk factor for type 2 diabetes and cardiovascular disease. Although associations of adiponectin with central obesity and insulin resistance have been reported, very little data are available from studies using detailed measures of insulin sensitivity (S(I)) and/or body fat distribution in ethnic groups at high risk for metabolic disease. ⋯ Directly measured S(I), VAT, and SAT were independently correlated with adiponectin in Hispanic and African-American subjects. The inverse association of VAT with adiponectin was stronger in African-Americans compared with Hispanics, a finding that suggests possible ethnic differences in the effects of visceral obesity.