The Journal of clinical endocrinology and metabolism
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J. Clin. Endocrinol. Metab. · Jun 2008
Randomized Controlled Trial Multicenter StudyEffects of denosumab on bone mineral density and bone turnover in postmenopausal women.
Denosumab is an investigational fully human monoclonal antibody against receptor activator of nuclear factor-kappaB ligand, a mediator of osteoclastogenesis and osteoclast survival. ⋯ Twice-yearly denosumab increased BMD and decreased BTMs in early and later postmenopausal women.
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J. Clin. Endocrinol. Metab. · Jun 2008
Randomized Controlled TrialEffect of weight loss and exercise therapy on bone metabolism and mass in obese older adults: a one-year randomized controlled trial.
Although weight loss and exercise ameliorates frailty and improves cardiac risk factors in obese older adults, the long-term effect of lifestyle intervention on bone metabolism and mass is unknown. ⋯ Weight loss, even when combined with exercise, decreases hip BMD in obese older adults. It is not known whether the beneficial effects of weight loss and exercise on physical function lower the overall risk of falls and fractures, despite the decline in hip BMD.