The Journal of clinical endocrinology and metabolism
The most recent articles from:
December 2009
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J. Clin. Endocrinol. Metab. · Dec 2009
Randomized Controlled Trial Multicenter Study Comparative StudyComparison of combined bupropion and naltrexone therapy for obesity with monotherapy and placebo.
The efficacy of current centrally acting obesity pharmacotherapies is limited by compensatory mechanisms that mitigate weight loss. ⋯ NB caused gradual sustained weight loss over 48 wk; NB32 and NB16 demonstrated greater weight loss in the intent-to-treat population due to lower attrition rates. Further study is needed to demonstrate long-term efficacy and safety of NB.