The Journal of clinical endocrinology and metabolism
The most recent articles from:
October 2010
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J. Clin. Endocrinol. Metab. · Oct 2010
Randomized Controlled TrialGlucose dysregulation and neurological injury biomarkers in critically ill children.
Targeting normoglycemia with intensive insulin therapy (IIT) improved short-term outcome of pediatric intensive care unit (PICU) patients but increased the incidence of hypoglycemia. Both hyperglycemia and hypoglycemia may adversely affect the developing brain. ⋯ IIT in PICU did not evoke neurological damage detectable by circulating S100B and NSE, despite increased incidence of hypoglycemia. Elevated markers in patients with hypoglycemia were not caused by hypoglycemia itself but rather reflect an increased incidence of hypoglycemia in the most severely ill. This hypoglycemia risk appears difficult to capture by classical illness severity scores.