The Journal of clinical endocrinology and metabolism
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J. Clin. Endocrinol. Metab. · Mar 2014
Randomized Controlled Trial Multicenter Study Comparative StudyPasireotide versus octreotide in acromegaly: a head-to-head superiority study.
Biochemical control reduces morbidity and increases life expectancy in patients with acromegaly. With current medical therapies, including the gold standard octreotide long-acting-release (LAR), many patients do not achieve biochemical control. ⋯ Pasireotide LAR demonstrated superior efficacy over octreotide LAR and is a viable new treatment option for acromegaly.
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J. Clin. Endocrinol. Metab. · Mar 2014
Multicenter StudyLong-term follow-up in adrenal incidentalomas: an Italian multicenter study.
The long-term consequences of subclinical hypercortisolism (SH) in patients with adrenal incidentalomas (AIs) are unknown. ⋯ SH is associated with the risk of incident CVEs. Besides the clinical follow-up, in patients with an AI >2.4 cm, a long-term biochemical follow-up is also required because of the risk of SH development.