The Journal of clinical endocrinology and metabolism
The most recent articles from:
September 2020
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J. Clin. Endocrinol. Metab. · Sep 2020
Meta AnalysisInsulin Sensitizers for Improving the Endocrine and Metabolic Profile in Overweight Women With PCOS.
To evaluate the efficacy of insulin sensitizers on menstrual frequency, sex hormone, and metabolic parameters in overweight women with polycystic ovary syndrome (PCOS). ⋯ For overweight women with PCOS, both metformin combined with GLP-1 receptor agonists and metformin combined with TZDs appear superior to monotherapy in improving hyperandrogenemia. Metformin combined with TZDs could be particularly effective in promoting the recovery of menstruation. Metformin combined with GLP-1 receptor agonists has the additional advantage of improving fasting glucose when compared with GLP-1 receptor agonists alone. TZDs are inferior to metformin in decreasing BMI.