J Orofac Pain
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To investigate whether local administration of nerve growth factor (NGF) decreases the mechanical threshold (MT) of putative nociceptive masseter afferent fibers as part of its mechanism of mechanical sensitization. ⋯ The finding that neither rat nor human NGF excited putative nociceptive masseter afferent fibers is consistent with a previous report that intramuscular NGF injections are not acutely painful in human subjects. The ability of human NGF injection into the rat masseter muscle to induce afferent mechanical sensitization suggests that this experimental approach may be useful for the study of peripheral mechanisms of myofascial pain and tenderness associated with temporomandibular disorders.
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Randomized Controlled Trial
Effects of local serotonin administration on pain and microcirculation in the human masseter muscle.
To investigate whether exogenously administered 5-hydroxytryptamine (5-HT) at high or low concentration influences pain and microcirculation in the human masseter muscle. ⋯ Intramuscular administration of 5-HT at 1,000 micromol/L into the human masseter muscle induced pain, but 5-HT did not have any effect on local blood flow at either concentration.
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To evaluate the effect of comorbid depression and pain on an early biopsychosocial intervention for acute temporomandibular disorder (TMD) patients. ⋯ With appropriate early biopsychosocial intervention, acute TMD patients, regardless of the presence or absence of vulnerability to depression symptomatology, can be effectively treated.
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To examine the psychometric characteristics of a measure of self-efficacy for managing temporomandibular disorders (TMD) and to determine whether scores on this measure were related to pain, disability, and psychological distress in patients with chronic TMD pain. ⋯ Self-efficacy for managing pain appears to be important in the adjustment of patients with chronic TMD pain. Research is needed to determine whether treatments designed to increase self-efficacy improve TMD patient outcomes.
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To investigate the degree and duration of neuronal hyperexcitability due to local inflammatory trauma after surgical removal of an impacted mandibular third molar. ⋯ These results indicate that even a minor surgical procedure in the orofacial region may be sufficient to evoke hyperexcitability in an area adjacent to the surgical wound for up to 30 days. The decreased adaptive capacity in the patient group also suggests the involvement of central pain-regulatory mechanisms in response to the surgical trauma.