J Orofac Pain
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To estimate the prevalence and pattern of self-reported orofacial pain symptoms and treatment-seeking behavior in adult Cantonese-speaking Chinese people in Hong Kong. ⋯ Orofacial pain symptoms appear to affect more than a quarter of the adult population in Hong Kong, and prevalence estimates were consistent with those in Western countries. A substantial proportion of the pain symptoms were frequent and of moderate to severe intensity, with the potential for significant morbidity. Professional treatment seeking was very low and may be related to specific pain behaviors and effective coping strategies in this ethnic group.
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To investigate whether local administration of nerve growth factor (NGF) decreases the mechanical threshold (MT) of putative nociceptive masseter afferent fibers as part of its mechanism of mechanical sensitization. ⋯ The finding that neither rat nor human NGF excited putative nociceptive masseter afferent fibers is consistent with a previous report that intramuscular NGF injections are not acutely painful in human subjects. The ability of human NGF injection into the rat masseter muscle to induce afferent mechanical sensitization suggests that this experimental approach may be useful for the study of peripheral mechanisms of myofascial pain and tenderness associated with temporomandibular disorders.
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Comparative Study
Cyclic effects on experimental pain response in women with temporomandibular disorders.
Since cyclic effects on experimental pain response in women with temporomandibular disorders (TMD) have not been adequately studied, the aim of this study was to assess variations in experimental pain response at 4 phases of the menstrual cycle. ⋯ Phase-related differences in experimental pain response were not strong and were more often found for experimental stimuli with greater clinical relevance (ie, palpation pain) compared with an ischemic pain task.
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To determine temporal changes in the concentrations found in the temporomandibular joint (TMJ) and trigeminal ganglion of 3 specific classes of inflammatory mediators commonly linked with conditions of joint inflammation. The intent was to determine whether concentrations of the neuropeptide calcitonin gene-related peptide (CGRP), the neurotrophin nerve growth factor (NGF), and the proinflammatory cytokines interleukin-1beta (IL1beta) and tumor necrosis factor-alpha (TNF-alpha) are altered in the trigeminal ganglion and TMJ tissues during various stages of adjuvant-induced inflammation of the rat TMJ. ⋯ The results suggest that the development of CFA-induced inflammation of the TMJ was accompanied by a variable increase in the concentration of different classes of inflammatory mediators in both the trigeminal ganglion and TMJ tissues, which implies that each class of inflammatory mediator may play a significant role during different stages in the onset and exacerbation of the inflammatory process.
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Randomized Controlled Trial Comparative Study Clinical Trial
Pain effects of glutamate injections into human jaw or neck muscles.
To document and compare the intensity, localization, and quality of pain evoked by glutamate injections into the human masseter or splenius muscles and to determine the effect of glutamate-evoked pain on the pressure pain thresholds (PPTs) in both jaw and neck muscles. ⋯ The data suggest that the masseter muscle is more sensitive to glutamate injections and mechanical stimuli than the splenius muscle. The relatively limited overlap between the sensory manifestations of pain from masseter and splenius muscles may have potential implications for diagnosis and management of myofascial pain complaints in the craniofacial and neck region.