J Cardiothorac Surg
The most recent articles from:
J Cardiothorac Surg
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J Cardiothorac Surg · May 2011
Comparative Study Retracted PublicationRapamycin-loaded nanoparticles for inhibition of neointimal hyperplasia in experimental vein grafts.
Nanoparticles possess several advantages as a carrier system for intracellular delivery of therapeutic agents. Rapamycin is an immunosuppressive agent which also exhibits marked antiproliferative properties. We investigated whether rapamycin-loaded nanoparticles(NPs) can reduce neointima formation in a rat model of vein graft disease. ⋯ We conclude that sustained-release rapamycin from rapymycin loaded NPs inhibits vein graft thickening without affecting the reendothelialization in rat carotid vein-to-artery interposition grafts and this may be a promising therapy for the treatment of vein graft disease.