The Journal of pediatrics
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The Journal of pediatrics · Dec 2001
Randomized Controlled Trial Multicenter Study Clinical TrialA two-year randomized, placebo-controlled trial of dornase alfa in young patients with cystic fibrosis with mild lung function abnormalities.
Our objective was to determine whether long-term treatment of young patients with cystic fibrosis (CF) with dornase alfa maintains lung function and reduces respiratory tract exacerbations. ⋯ Treatment of young patients with CF with dornase alfa maintains lung function and reduces the risk of exacerbations over a 96-week period.
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The Journal of pediatrics · Dec 2001
Randomized Controlled Trial Clinical TrialImpact of chronic transfusion on incidence of pain and acute chest syndrome during the Stroke Prevention Trial (STOP) in sickle-cell anemia.
The Stroke Prevention Trial (STOP) demonstrated that chronic transfusion is highly effective in reducing the risk of stroke in children with sickle-cell disease and an abnormal transcranial Doppler ultrasonography examination result. Our objective was to determine whether chronic transfusion therapy reduces the incidence of pain and acute chest syndrome. ⋯ Compliance with aggressive chronic transfusion reduces the frequency of acute chest syndrome and pain episodes.