The Journal of pediatrics
-
The Journal of pediatrics · May 2011
Multicenter Study Comparative StudyOff-label recombinant factor VIIa use and thrombosis in children: a multi-center cohort study.
To describe the off-label use of recombinant factor VIIa (rFVIIa) in tertiary care pediatric hospitals across the United States and to assess thrombotic events. ⋯ The off-label use of rFVIIa in hospitalized children is increasing rapidly despite the absence of adequate clinical trials demonstrating safety and efficacy. Thrombotic events are common and mortality is high among patients receiving off-label rFVIIa. Further studies are warranted to determine whether these adverse events are attributable to rFVIIa.