The Journal of pediatrics
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The Journal of pediatrics · Feb 2012
Multicenter StudyWidespread use of fresh frozen plasma in US children's hospitals despite limited evidence demonstrating a beneficial effect.
To determine the pattern, prevalence and potential complications of fresh frozen plasma (FFP) use in US pediatric hospitals from 2002-2009. ⋯ FFP is commonly used in children admitted to PHIS hospitals. Despite recent expert recommendations highlighting the lack of efficacy in many clinical scenarios, the rate of FFP use does not appear to be changing. Randomized, controlled studies are needed to determine appropriate indications for FFP use and evaluate for potential complications.
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The Journal of pediatrics · Feb 2012
Multicenter StudyCoagulopathy is prevalent and associated with adverse outcomes in transfused pediatric trauma patients.
To evaluate coagulopathy in pediatric trauma patients on presentation to the emergency department, and to quantify the relationship with mortality. ⋯ Coagulopathy is prevalent in pediatric trauma patients ill enough to require a transfusion and is strongly associated with mortality. Studies are needed to determine whether early coagulation factor replacement and the institution of massive transfusion protocols may improve outcomes in these patients.