The Journal of pediatrics
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The Journal of pediatrics · Nov 2013
Multicenter StudyAntithrombin concentrate use in children: a multicenter cohort study.
To describe the off-label use of antithrombin concentrate in tertiary care pediatric hospitals across the US. ⋯ The off-label use of antithrombin concentrate is increasing rapidly, particularly in critically ill children receiving extracorporeal membrane oxygenation, with few parallel studies to substantiate its safety or efficacy. Further preclinical and controlled clinical studies are critical to expanding our knowledge of this drug. In the meantime, antithrombin concentrate should be used judiciously by clinicians and following guidelines instated by hospitals.