The Journal of pediatrics
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The Journal of pediatrics · Sep 2013
Randomized Controlled Trial Multicenter StudyEfficacy and safety of continuous infusion of fentanyl for pain control in preterm newborns on mechanical ventilation.
To evaluate the analgesic superiority and the safety equivalence of continuous fentanyl infusions versus fentanyl boluses in preterm infants on mechanical ventilation. ⋯ In very preterm infants on mechanical ventilation, continuous fentanyl infusion plus open-label boluses of fentanyl does not reduce prolonged pain, but does reduce acute pain and increase side effects compared with open-label boluses of fentanyl alone.