The Journal of pediatrics
-
The Journal of pediatrics · Mar 2014
Biomarkers for severity of neonatal hypoxic-ischemic encephalopathy and outcomes in newborns receiving hypothermia therapy.
To evaluate serum neuronal and inflammatory biomarkers to determine whether measurements of umbilical cords at birth can stratify severity of hypoxic-ischemic encephalopathy (HIE), whether serial measurements differ with hypothermia-rewarming, and whether biomarkers correlate with neurological outcomes. ⋯ The severity of the hypoxic-ischemic injury can be stratified at birth because elevated neuronal biomarkers in cord serum correlated with severity of HIE and outcomes.
-
The Journal of pediatrics · Mar 2014
Pretransplant serum albumin is an independent predictor of graft failure in pediatric renal transplant recipients.
To determine the prevalence of hypoalbuminemia in children listed for renal transplantation and to evaluate the effect of pretransplant hypoalbuminemia on posttransplant outcomes. ⋯ Considerable regional variation exists in the US with respect to transplantation in children with hypoalbuminemia. Severe hypoalbuminemia is an independent risk factor for graft failure. Transplant centers as well as patients need to be aware of this risk and make informed decisions regarding the optimal timing of transplantation. Whether graft failure is a consequence of the low serum albumin or the reflection of a higher inflammatory milieu remains to be explored.
-
The Journal of pediatrics · Mar 2014
Functional outcomes in children with abusive head trauma receiving inpatient rehabilitation compared with children with nonabusive head trauma.
To compare clinical features and functional outcomes of age- and sex-matched children with abusive and nonabusive head trauma receiving inpatient rehabilitation. ⋯ Despite more associated injuries, children with abusive head trauma make significant functional gains during inpatient rehabilitation, comparable with an age- and sex-matched sample with nonabusive head trauma. Key functional skills may be gained by children in both groups following discharge from inpatient rehabilitation.
-
The Journal of pediatrics · Mar 2014
Implementation of lipid screening guidelines in children by primary pediatric providers.
To assess the awareness and implementation of lipid guidelines among primary pediatric providers. ⋯ These findings underscore the need to further educate providers and supply easily accessible information on the screening and treatment of childhood lipid disorders.
-
The Journal of pediatrics · Mar 2014
Pulse oximetry is insufficient for timely diagnosis of hepatopulmonary syndrome in children with liver cirrhosis.
To prospectively investigate the prevalence of hepatopulmonary syndrome (HPS), the importance of pulse oximetry in diagnosing HPS, and the longitudinal course after liver transplantation in children with cirrhosis referred for liver transplantation. ⋯ IPVD is frequent in children with liver cirrhosis (40%). Pulse oximetry is insufficient for timely HPS diagnosis. Pathological CBG analysis data indicate IPVD in the majority of cases, but are imprecise in children aged <2 years. Contrast-enhanced transthoracic echocardiography and CBG analysis are recommended for evaluation of HPS in children with cirrhosis, regardless of liver synthesis capacity and clinical chemistry data.