The Journal of pediatrics
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The Journal of pediatrics · May 2011
Multicenter Study Comparative StudyOff-label recombinant factor VIIa use and thrombosis in children: a multi-center cohort study.
To describe the off-label use of recombinant factor VIIa (rFVIIa) in tertiary care pediatric hospitals across the United States and to assess thrombotic events. ⋯ The off-label use of rFVIIa in hospitalized children is increasing rapidly despite the absence of adequate clinical trials demonstrating safety and efficacy. Thrombotic events are common and mortality is high among patients receiving off-label rFVIIa. Further studies are warranted to determine whether these adverse events are attributable to rFVIIa.
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The Journal of pediatrics · Apr 2011
Randomized Controlled Trial Multicenter StudyInfliximab for intravenous immunoglobulin resistance in Kawasaki disease: a retrospective study.
To test the hypothesis that first re-treatment with infliximab, compared with intravenous immunoglobulin (IVIG), might improve outcomes in IVIG-resistant Kawasaki disease. ⋯ In our retrospective study, patients with IVIG-resistant Kawasaki disease whose first re-treatment was with infliximab, compared with IVIG, had faster resolution of fever and fewer days of hospitalization. Coronary artery outcomes and adverse events were similar; the power of the study was limited.
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The Journal of pediatrics · Mar 2011
Multicenter StudyChildhood onset inflammatory bowel disease: predictors of delayed diagnosis from the CEDATA German-language pediatric inflammatory bowel disease registry.
To examine predictors of delayed diagnosis of inflammatory bowel disease in children and adolescents. ⋯ There is still concern about delays in the diagnosis of inflammatory bowel disease in the very young and in children with small bowel disease. Inequalities of care by region require further investigation.
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The Journal of pediatrics · Nov 2010
Multicenter StudyVentilation practices in the neonatal intensive care unit: a cross-sectional study.
To assess current ventilation practices in newborn infants. ⋯ Time cycled pressure-limited ventilation is the most commonly used mode in neonatal ventilation. Tidal volumes are usually targeted between 4 to 7 mL/kg and positive end-expiratory pressure between 4 to 6 cmH(2)O. Newer ventilation modes are only used in a minority of patients.
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The Journal of pediatrics · Sep 2010
Randomized Controlled Trial Multicenter StudySelective head cooling with mild systemic hypothermia after neonatal hypoxic-ischemic encephalopathy: a multicenter randomized controlled trial in China.
To investigate the efficacy and safety of selective head cooling with mild systemic hypothermia in hypoxic-ischemic encephalopathy (HIE) in newborn infants. ⋯ Selective head cooling combined with mild systemic hypothermia for 72 hours may significantly decrease the combined outcome of severe disability and death, as well as severe disability.