The Journal of pediatrics
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The Journal of pediatrics · Aug 2003
Acute chylothorax in children: selective retention of memory T cells and natural killer cells.
To assess for immunodeficiency in patients with hypogammaglobulinemia in the setting of draining acute chylothorax. ⋯ Draining chylothorax resulted in IgG and lymphocyte depletion with preferential retention of memory T cells and natural killer cells in the circulation. Overall, protective-specific antibody levels and T cell function were maintained. IVIG administration did not lead to discernible protection from infectious complications in this small group of patients.
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The Journal of pediatrics · Jul 2003
Randomized Controlled Trial Clinical TrialEffect of ganciclovir therapy on hearing in symptomatic congenital cytomegalovirus disease involving the central nervous system: a randomized, controlled trial.
To evaluate the efficacy and safety of ganciclovir therapy in neonates with congenital cytomegalovirus (CMV) disease. ⋯ Ganciclovir therapy begun in the neonatal period in symptomatically infected infants with CMV infection involving the central nervous system prevents hearing deterioration at 6 months and may prevent hearing deterioration at > or =1 year. Almost two thirds of treated infants have significant neutropenia during therapy.
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The Journal of pediatrics · May 2003
Clinical TrialRelations between exhaled nitric oxide and measures of disease activity among children with mild-to-moderate asthma.
Exhaled nitric oxide (FE(NO)) was evaluated in children with asthma after 4 to 6 years of treatment with budesonide, nedocromil, or albuterol as needed. ⋯ Budesonide therapy was more effective than nedocromil in reducing FE(NO). Unfortunately, the effects of long-term budesonide were not sustained after its discontinuation. FE(NO) may be a complementary tool to current practice guidelines in assessing asthma control and medication response.