The Journal of pediatrics
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The Journal of pediatrics · Dec 2001
Beneficial effects of intensive therapy of diabetes during adolescence: outcomes after the conclusion of the Diabetes Control and Complications Trial (DCCT).
The Diabetes Control and Complications Trial (DCCT) demonstrated that intensive therapy of type 1 diabetes mellitus reduces the risk of development and progression of microvascular complications. The Epidemiology of Diabetes Interventions and Complications (EDIC) study assessed whether these benefits persisted after the end of DCCT. Results for the adolescent DCCT cohort are reported here. ⋯ These findings provide further support for the DCCT recommendation that most adolescents with type 1 diabetes receive intensive therapy aimed at achieving glycemic control as close to normal as possible to reduce the risk of microvascular complications.
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The Journal of pediatrics · Oct 2001
Clinical TrialDouble catheter technique for misdirected umbilical vein catheter.
We studied the success rate of the double catheter technique during umbilical vein catheter placement in 42 patients with a misdirected umbilical vein catheter. The misdirected catheter was left in place, and an additional catheter was inserted. X-ray films confirmed that successful placement was achieved in 50% of infants without significant adverse effects.
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The Journal of pediatrics · Sep 2001
Maternal and infant use of erythromycin and other macrolide antibiotics as risk factors for infantile hypertrophic pyloric stenosis.
To evaluate the risk for infantile hypertrophic pyloric stenosis (IHPS) among infants prescribed systemic erythromycin, infants prescribed a course of erythromycin ophthalmic ointment, and infants whose mothers were prescribed a macrolide antibiotic during pregnancy. ⋯ This study confirms an association between systemic erythromycin in infants and subsequent IHPS, with the highest risk in the first 2 weeks of age. No association was found with erythromycin ophthalmic ointment. A possible association with maternal macrolide therapy in late pregnancy requires further study. Systemic erythromycin should be used with prudence in early infancy.
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The Journal of pediatrics · Sep 2001
Clinical TrialSerum ionized magnesium in post-traumatic headaches.
The objective of this study was to determine the values of serum ionized magnesium, total magnesium, and ionized calcium/ionized magnesium ratios in children with headaches. One hundred thirty-five children with primary complaints of headaches were classified according to the criteria of the International Headache Society. Blood samples were obtained and tested for ionized magnesium (IMg(2+)), total magnesium, ionized calcium (ICa(2+)), and pH. ⋯ Nine children were given a diagnosis of post-traumatic headache. Six of them had statistically significant (P <.05) lowered IMg(2+) levels and high ICa(2+)/IMg(2+) ratios. Abnormalities in serum IMg(2+) concentrations and ICa(2+)/IMg(2+) ratios were found in children with post-traumatic headaches, but total magnesium levels were normal.