The Journal of pediatrics
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The Journal of pediatrics · Mar 2009
Randomized Controlled Trial Comparative StudyInterventions to reduce pain during vaccination in infancy.
To investigate interventions that affect pain reduction during vaccination in infants and children attending a well-child unit. ⋯ Here we expand on previous findings by demonstrating that breast-feeding may have an analgesic effect up to age 6 months and that in older children, both sucrose and lidocaine-prilocaine reduce vaccination pain.
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The Journal of pediatrics · Feb 2009
Randomized Controlled TrialRandomized trial of milrinone versus placebo for prevention of low systemic blood flow in very preterm infants.
To assess the effectiveness of early prophylactic milrinone versus placebo for prevention of low systemic blood flow in high-risk preterm infants. ⋯ Milrinone did not prevent low systemic blood flow during the first 24 hours in very preterm infants, and no adverse effects were attributable to milrinone. Use of a preventative treatment with rescue model allowed comparison of an inotrope with placebo in this high-risk group of infants.
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The Journal of pediatrics · Dec 2008
Randomized Controlled Trial Multicenter StudyInfliximab treatment of intravenous immunoglobulin-resistant Kawasaki disease.
To investigate the safety, tolerability, and pharmacokinetics of the anti-tumor necrosis factor-alpha monoclonal antibody infliximab in subjects with intravenous immunoglobulin (IVIG)-resistant Kawasaki disease (KD). ⋯ Both infliximab and a second IVIG infusion were safe and well tolerated in the subjects with KD who were resistant to standard IVIG treatment. The optimal management of patients resistant to IVIG remains to be determined.
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The Journal of pediatrics · Mar 2008
Randomized Controlled TrialA novel needle-free powder lidocaine delivery system for rapid local analgesia.
To determine the analgesic effect and tolerability of a novel needle-free powder lidocaine delivery system in children undergoing venipuncture. ⋯ The needle-free powder lidocaine delivery system was well tolerated and provided effective local analgesia when administered 2 to 3 minutes before venipuncture.
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The Journal of pediatrics · Mar 2008
Randomized Controlled TrialEffect of an integrated care pathway on acute asthma/wheeze in children attending hospital: cluster randomized trial.
To determine whether an integrated care pathway (ICP) could improve care delivered to patients coming to an emergency department only or to patients who were subsequently admitted. ⋯ An acute asthma/wheeze ICP improved education and prescribing errors, modestly reduced the length of stay when discharge criteria were adhered to, but did not influence recovery time. Further consideration of the effect on staff workload is required.