The Journal of pediatrics
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The Journal of pediatrics · Jul 2011
Review Meta AnalysisTonsillectomy in children with periodic fever with aphthous stomatitis, pharyngitis, and adenitis syndrome.
To seek evidence supporting a role for tonsillectomy or adenotonsillectomy in the management of affected children with periodic fever with aphthous stomatitis, pharnygitis, and adenitis (PFAPA) syndrome. ⋯ Surgery appears to be a possible option for management of PFAPA syndrome. Available evidence is limited, however, and the precise role of surgery remains to be clarified. We suggest considering this option when symptoms markedly interfere with the child's quality of life and medical treatment has failed.
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The Journal of pediatrics · Sep 2006
Meta AnalysisProbiotics in the prevention of antibiotic-associated diarrhea in children: a meta-analysis of randomized controlled trials.
To systematically evaluate the effectiveness of probiotics in preventing antibiotic-associated diarrhea (AAD) in children. ⋯ Probiotics reduce the risk of AAD in children. For every 7 patients that would develop diarrhea while being treated with antibiotics, one fewer will develop AAD if also receiving probiotics.
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The Journal of pediatrics · Dec 1997
Meta Analysis Comparative StudyA meta-analytic review of the preventive treatment of recurrences of febrile seizures.
To assess the efficacy of various medications in the prevention of recurrent febrile seizures. ⋯ Because both agents found to be effective in prevention of recurrent febrile seizures have known adverse effects, prophylaxis of febrile seizures cannot be recommended.
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The Journal of pediatrics · Apr 1994
Meta AnalysisRisk factors for seizure recurrence in children with febrile seizures: a pooled analysis of individual patient data from five studies.
To reassess the relations between postulated risk factors and seizure recurrence after a first febrile seizure (FS), the individual data from five follow-up studies that used similar definitions of FSs and risk factors were pooled and reanalyzed. The risk of frequent recurrent seizures and of the occurrence of complex seizures in previously healthy, untreated children was studied. Seizure recurrence hazard was described as a function of the child's attained age. ⋯ Young age at onset (< 12 months), a family history of unprovoked seizures, and a partial initial FS were all associated with an increased risk of complex seizures. A higher recurrence rate in clinic-based studies compared with population-based studies could not be explained by a difference in the presence of the risk factors studied. Thus other factors must influence seizure recurrence after an initial FS.