The Journal of pediatrics
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The Journal of pediatrics · Jul 2007
Randomized Controlled Trial Multicenter StudyPalivizumab prophylaxis, respiratory syncytial virus, and subsequent recurrent wheezing.
Children who experience respiratory syncytial virus (RSV) lower respiratory tract infections (LRTIs) early in life have high rates of subsequent recurrent wheezing. Palivizumab, an anti-RSV monoclonal antibody, has 78% to 80% efficacy in preventing RSV hospitalization in premature infants without chronic lung disease. We hypothesized that palivizumab, by ameliorating or preventing early RSV LRTI in preterm infants, might decrease later recurrent wheezing. ⋯ Our study suggests that preventing RSV LRTI with palivizumab may reduce subsequent recurrent wheezing in premature infants.
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The Journal of pediatrics · May 2007
Randomized Controlled Trial Comparative StudyNasal intermittent mandatory ventilation versus nasal continuous positive airway pressure for respiratory distress syndrome: a randomized, controlled, prospective study.
To evaluate whether nasal intermittent mandatory ventilation (NIMV) compared with nasal continuous positive airway pressure (NCPAP) would decrease the requirement for endotracheal ventilation in the treatment of respiratory distress syndrome (RDS) in preterm infants <35 weeks. ⋯ NIMV compared with NCPAP decreased the requirement for endotracheal ventilation in premature infants with RDS. This was associated with a decreased incidence of BPD.
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The Journal of pediatrics · Nov 2006
Randomized Controlled Trial Multicenter StudySafety of reduced-antigen-content tetanus-diphtheria-acellular pertussis vaccine in adolescents as a sixth consecutive dose of acellular pertussis-containing vaccine.
The safety of a booster dose of a reduced-antigen-content tetanus-diphtheria-acellular pertussis (Tdap) vaccine was evaluated in adolescents previously vaccinated with five doses of acellular pertussis-containing vaccine. ⋯ These results suggest that Tdap is well tolerated as a sixth consecutive dose of acellular pertussis-containing vaccine.
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The Journal of pediatrics · Sep 2006
Randomized Controlled TrialThe Premature Infants in Need of Transfusion (PINT) study: a randomized, controlled trial of a restrictive (low) versus liberal (high) transfusion threshold for extremely low birth weight infants.
To determine whether extremely low birth weight infants (ELBW) transfused at lower hemoglobin thresholds versus higher thresholds have different rates of survival or morbidity at discharge. ⋯ In extremely low birth weight infants, maintaining a higher hemoglobin level results in more infants receiving transfusions but confers little evidence of benefit.
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The Journal of pediatrics · Jun 2006
Randomized Controlled Trial Comparative StudyNeonatal laryngoscope intubation and the digital method: a randomized controlled trial.
We compared digital intubation (DI) and laryngoscope intubation (LI) in newborns. The success rate was 90.5% for DI and 50% for LI (P = .004). It took 8.2 seconds to complete the DI and 13.1 seconds to complete the LI (P = .007). DI should be considered to be an option for neonatal intubation.