The Journal of pediatrics
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The Journal of pediatrics · Mar 1996
Multicenter Study Comparative StudyEffectiveness of ribavirin in otherwise well infants with respiratory syncytial virus-associated respiratory failure. Pediatric Critical Study Group.
To examine ribavirin's effectiveness in otherwise well infants with respiratory syncytial virus (RSV)-associated respiratory failure. ⋯ Ribavirin administration during mechanical ventilation to previously well infants with RSV infection was not associated with reductions in either mortality rates or duration of mechanical ventilation. Additional clinical effectiveness studies are required to define specific groups in which the use of aerosolized ribavirin is indicated.
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The Journal of pediatrics · Mar 1996
Multicenter Study Comparative StudyLow-molecular-weight heparin in pediatric patients with thrombotic disease: a dose finding study.
To compare low-molecular-weight preparations of heparin (LMWH) with standard heparin in children requiring anticoagulant treatment for thromboembolic disease. ⋯ These results provide the basis for a randomized, controlled trial comparing LMWH with standard heparin in pediatric patients.
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The Journal of pediatrics · Mar 1996
Randomized Controlled Trial Multicenter Study Comparative Study Clinical TrialA multicenter randomized, masked comparison trial of natural versus synthetic surfactant for the treatment of respiratory distress syndrome.
To compare the efficacy and safety of two surfactant preparations in the treatment of respiratory distress syndrome (RDS). ⋯ Compared with Exosurf, Infasurf provided more effective therapy for RDS as assessed by significant reductions in the severity of respiratory disease and in the incidence of air leak complications.
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The Journal of pediatrics · Jan 1996
Multicenter StudyVariability in duration of stay in pediatric intensive care units: a multiinstitutional study.
Development of a statistical model to predict length of stay (LOS) in a pediatric intensive care unit (PICU) that adjusts for patient-related risk factors at admission. ⋯ The predictor can be used to adjust LOS in PICUs for patient-related risk factors, enabling the comparison of resource utilization among different institutions. Organizational factors known to foster team-oriented care are associated with shorter LOS, whereas increased relative PICU size may pose an incentive to keep PICU beds occupied longer.
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The Journal of pediatrics · Nov 1995
Randomized Controlled Trial Multicenter Study Comparative Study Clinical TrialDiscontinuing penicillin prophylaxis in children with sickle cell anemia. Prophylactic Penicillin Study II.
To evaluate the consequences of discontinuing penicillin prophylaxis at 5 years of age in children with sickle cell anemia who had received prophylactic penicillin for much of their lives. ⋯ Children with sickle cell anemia who have not had a prior severe pneumococcal infection or a splenectomy and are receiving comprehensive care may safely stop prophylactic penicillin therapy at 5 years of age. Parents must be aggressively counseled to seek medical attention for all febrile events in children with sickle cell anemia.