The Journal of pediatrics
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The Journal of pediatrics · Aug 2014
Randomized Controlled Trial Multicenter StudyTotal body polyethylene wraps for preventing hypothermia in preterm infants: a randomized trial.
To evaluate whether a polyethylene total body wrapping (covering both the body and head) is more effective than conventional treatment (covering up to the shoulders) in reducing perinatal thermal losses in very preterm infants. ⋯ Total body wrapping is comparable with covering the body up to the shoulders in preventing postnatal thermal losses in very preterm infants.
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The Journal of pediatrics · Aug 2014
Randomized Controlled Trial Multicenter StudyRespiratory outcomes of the surfactant positive pressure and oximetry randomized trial (SUPPORT).
To explore the early childhood pulmonary outcomes of infants who participated in the National Institute of Child Health and Human Development's Surfactant Positive Airway Pressure and Pulse Oximetry Randomized Trial (SUPPORT), using a factorial design that randomized extremely preterm infants to lower vs higher oxygen saturation targets and delivery room continuous positive airway pressure (CPAP) vs intubation/surfactant. ⋯ Treatment with early CPAP rather than intubation/surfactant is associated with less respiratory morbidity by 18-22 months CA. Longitudinal assessment of pulmonary morbidity is necessary to fully evaluate the potential benefits of respiratory interventions for neonates.
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The Journal of pediatrics · Aug 2014
Randomized Controlled TrialSchool-age outcomes following a randomized controlled trial of magnesium sulfate for neuroprotection of preterm infants.
In a French randomized trial, children at school-age demonstrated no evidence of harm from fetal exposure to MgSO4 before very preterm birth. Motor dysfunction/death, qualitative behavioral disorders, cognitive difficulties, school grade repetition, and education services were decreased in the children exposed to MgSO4, although the differences were not significant.
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The Journal of pediatrics · Jul 2014
Randomized Controlled TrialRandomized controlled trial of oxygen saturation targets in very preterm infants: two year outcomes.
To assess whether an oxygen saturation (Spo2) target of 85%-89% compared with 91%-95% reduced the incidence of the composite outcome of death or major disability at 2 years of age in infants born at <28 weeks' gestation. ⋯ Although there was no benefit or harm from targeting a lower compared with a higher saturation in this trial, further information will become available from the prospectively planned meta-analysis of this and 4 other trials comprising a total of nearly 5000 infants.
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The Journal of pediatrics · Jul 2014
Randomized Controlled TrialBotulinum toxin A for nonambulatory children with cerebral palsy: a double blind randomized controlled trial.
To examine the efficacy and safety of intramuscular botulinum toxin A (BoNT-A) to reduce spasticity and improve comfort and ease of care in nonambulant children with cerebral palsy (CP). ⋯ In a double-blind randomized sham-controlled trial, intramuscular BoNT-A and therapy were effective for improving ease of care and comfort for nonambulant children with CP. There was no increase in moderate and severe AE in the children who had BoNT-A injections compared with the sham group.